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Creon medication5/10/2023 If dose requires more than 2 capsules, repeat the above steps until the desired dose is achieved. Discard any unused portion of the mixture. Flush the gastrostomy tube with approximately 10 mL of water. Connect the syringe directly into the gastrostomy tube feeding port and push the syringe contents using steady pressure until empty. Shake or tap the syringe lightly with the syringe tip facing upward and carefully push the plunger slowly until the residual air is removed. Replace the plunger partially back into the syringe. While covering the tip of the syringe with a finger, transfer the Pertzye-applesauce mixture into the syringe. Remove the plunger from a 35 mL slip tip syringe. Mix the capsule contents thoroughly with the transferred applesauce to create a uniform suspension. Transfer at least 10 mL of applesauce into a small bowl or medicine cup. Pertzye 4,000 USP lipase unit capsules (14 Fr gastrostomy tube or larger no more than 2 capsules may be administered at a time) Consider the feeding tube size, feeding schedule (continuous or intermittent), pancrease product (specifically the size of the microspheres/beads), and other concurrent medications (i.e., medications that suppress gastric acid production) when determining the most appropriate method of administration for a specific patient. Administration of pancrelipase products via a gastrostomy tube presents a complex challenge the risk of clogging the feeding tube must be balanced with the risk of reducing enzyme effectiveness. Do not mix directly with infant formula or breast-milk. Administer water, juice, or breast milk/formula immediately after the dose to ensure no enzymes remain in the mouth. The soft food mixture should be swallowed immediately without chewing. For patients unable to swallow whole capsules, the capsules may be opened and the contents administered with soft acidic food (pH 4 or 4.5 or less, e.g., commercially available preparations of bananas, pears, and applesauce). The enteric coating will dissolve if in prolonged contact with foods having a pH more than 5.5, which may reduce efficacy. Do not chew or crush to avoid destruction of enteric coating. Follow oral dosage with a glass of water or juice (or formula or breast milk for infants). Do not retain preparations in the mouth prior to swallowing because the enzymes can cause mucosal irritation and stomatitis. Administer with or immediately prior to meals and snacks. For storage information, see the specific product information within the How Supplied section.
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